A family of cyclin homologs that control the G1 phase in yeast
作者： J. A. Hadwiger , C. Wittenberg , H. E. Richardson , M. de Barros Lopes , S. I. Reed
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摘要: Abstract Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation the gene CDC28, which encodes protein kinase involved in control cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by dramatic periodicity abundance through cycle, are thought to be mitotic induction animal cells. A dominant gene, CLN2-1, advances G1- S-phase transition cycling cells impairs ability arrest G1 phase response external signals, suggesting encoded is cycle Saccharomyces.
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