Restoring motor function using optogenetics and neural engraftment
作者： J Barney Bryson , Carolina Barcellos Machado , Ivo Lieberam , Linda Greensmith
DOI: 10.1016/J.COPBIO.2016.02.016
关键词: Amyotrophic lateral sclerosis 、 Neural stem cell 、 Neuroscience 、 Optogenetics 、 Motor function 、 Muscle paralysis 、 Control muscle 、 Traumatic spinal cord injury 、 Medicine 、 In patient 、 Biotechnology 、 Bioengineering 、 Biomedical engineering
摘要: Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor paralysis can severely impact quality life may be immediately life-threatening, as occurs in many cases traumatic spinal cord injury (SCI) patients with amyotrophic lateral sclerosis (ALS). Repairing damaged circuits, either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control thereby enable tasks. This review focuses on recent advances towards restoring function, a particular focus stem cell-derived neuronal engraftment strategies, optogenetic the potential future translational application these approaches.
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