Quality by design based silymarin nanoemulsion for enhancement of oral bioavailability

摘要: Abstract Silymarin has been approved as a safe herbal hepatoprotective drug well of choice for several hepatic disorders. However it suffers from the problem poor oral bioavailability. In current work silymarin loaded nanoemulsions were prepared using high pressure homogenization (HPH) technique. Capryol 90, Solutol HS 15 and Transcutol HP selected oil phase, surfactant co-surfactant, respectively. Quality by design was employed to optimize nanoemulsion in terms amount surfactant/co-surfactant mixture (S mix ), processing number cycles. Globule size, polydispersity index (PDI), zeta potential, transmittance percentage in vitro release optimized formulation found 50.02 ± 4.5 nm, 0.45 ± 0.02, −31.49 mV, 100.00 ± 2.21% 90.00 ± 1.83%, The everted gut sac studies showed that facilitated improvement apparent permeability coefficient (P app ). P suspension 1.00 × 10 −5  cm/h with flux 0.422 μg/cm 2 /h 6.30 × 10 −6 0.254 μg/cm at 2 h, Pharmacokinetic study significantly (p