Nano-ropinirole for the management of Parkinsonism: blood-brain pharmacokinetics and carrier localization.
作者： Gulam Mustafa , Alka Ahuja , Abdulmohsen H Al Rohaimi , Shahnawaz Muslim , Allam A Hassan
DOI: 10.1586/14737175.2015.1036743
关键词:
摘要: Aim: The aim of this study was to investigate the brain targeting potential chitosan-coated oil in water nanoemulsions (CSNEROP) delivered intranasally haloperidol-induced Parkinson's disease rat models. Methods: Chitosan-coated nanoemulsion developed through aqueous titration followed by a high pressure homogenization method. Results: Gamma-scintigraphy showed significantly mucoadhesive CSNEROP and least for conventional homogenized formulations. Confocal deep localization formulations confirming permeation CSNEROP. Pharmacokinetic results Wistar plasma (p** < 0.005) AUC0→24 amplified Cmax over i.v treatment group. Neurobehavioral activity (rotarod swim tests) biochemical parameters (glutathion, TBARS SOD) corroborated well with pharmacokinetic results. order dopamine recovery rats found be i...
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