Curcumin Prevents Experimental Diabetic Retinopathy in Rats Through Its Hypoglycemic, Antioxidant, and Anti-Inflammatory Mechanisms
作者： Suresh Kumar Gupta , Binit Kumar , Tapas Chandra Nag , Shyam Sunder Agrawal , Renu Agrawal
关键词: Diabetic retinopathy 、 Curcumin 、 Diabetes mellitus 、 Vascular endothelial growth factor 、 Antioxidant 、 Endocrinology 、 Glutathione 、 Retinopathy 、 Medicine 、 Internal medicine 、 Superoxide dismutase
摘要: Abstract Purpose: The purpose of this study was to evaluate the therapeutic potential oral curcumin (1 g/kg body weight rat) in prevention and treatment streptozotocin-induced diabetic retinopathy Wistar albino rats. Methods: carried out for a period 16 weeks rats evaluated hyperglycemic, antioxidant (superoxide dismutase, catalase, glutathione), inflammatory parameters (tumor necrosis factor-α, vascular endothelial growth factor). Rat fundus observed weekly see any visible changes retina, such as tortuosity dilation retinal vessels. Histological were by transmission electron microscopy. Results: Treatment with showed significant hypoglycemic activity compared group. Retinal glutathione levels decreased 1.5-fold, enzymes, superoxide dismutase >2-fold decrease group; on other hand, positively ...
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