Integrative analyses reveal transcriptome-proteome correlation in biological pathways and secondary metabolism clusters in A. flavus in response to temperature.
作者： Youhuang Bai , Sen Wang , Hong Zhong , Qi Yang , Feng Zhang
DOI: 10.1038/SREP14582
关键词: Biological pathway 、 Secondary metabolism 、 Biochemistry 、 Aspergillus flavus 、 Transcriptome 、 Proteome 、 Fungal protein 、 KEGG 、 Biology 、 Gene expression profiling 、 Genetics
摘要: To investigate the changes in transcript and relative protein levels response to temperature, complementary transcriptomic proteomic analyses were used identify Aspergillus flavus grown at 28 °C 37 °C. A total of 3,886 proteins identified 2,832 reliably quantified. subset 664 was differentially expressed upon temperature enriched several Kyoto Encyclopedia Genes Genomes pathways: translation-related pathways, metabolic pathways biosynthesis secondary metabolites. The profiles showed low congruency with alterations corresponding levels, indicating that post-transcriptional processes play a critical role regulating level A. flavus. expression pattern transcripts related aflatoxin most genes up-regulated both 28 °C. Our data provide comprehensive quantitative proteome conducive nonconducive temperatures.
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