Hippocampal 3H-CPP binding and spatial learning deficits in aged rats

摘要: Recent evidence has shown that either intraventricular or intrahippocampal injection of the NMDA antagonist D-2-amino-5-phosphonovalerate (AP-5) produces a spatial learning deficit. This deficit is similar to observed in aged animals. The capacity rats could, then, be related changes status hippocampal receptors. study assessed receptor binding young and using potent 3H [(±)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid (CPP). Initial characterization experiments indicated 3H-CPP bound selectively class receptors tissue with high affinity (39.5 nM). was significantly reduced experimentally naive (24–25 months) as compared animals (5 months). A comparable reduction found comparison had been trained on task Morris water maze. Furthermore, correlated severity present within group. It concluded sites, measured by binding, may contribute emergence cognitive deficits