Gene expression and nuclear architecture during development and differentiation
DOI: 10.1016/J.MOD.2003.05.001
关键词: Scaffold/matrix attachment region 、 Nuclear lamina 、 Nuclear matrix 、 Biology 、 Cellular differentiation 、 Computational biology 、 Nucleus 、 Gene 、 Gene silencing 、 Transvection 、 Genetics
摘要: Development requires a precise program of gene expression to be carried out. Much work has focussed on the regulatory networks that control expression, for example in response external cues. However, it is important recognize these events take place within physical context nucleus, and position nuclear volume can have strong influences its regulation interactions. The first part this review will summarize what currently known about architecture, is, large-scale three-dimensional arrangement chromosome loci nucleus. remainder examine developmental processes from point view
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