Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation.
作者： Chandrika J Piyathilake , Gary L Johanning , Maurizio Macaluso , Martin Whiteside , Denise K Oelschlager
DOI: 10.1207/S15327914NC3701_13
关键词: Carcinogenesis 、 DNA hypomethylation 、 In vivo 、 Methylation 、 DNA methylation 、 Cyanocobalamin 、 Vitamin 、 Cancer research 、 Pathology 、 Epidermoid carcinoma 、 Medicine
摘要: We measured the concentrations of folate and vitamin B-12 in paired tissue samples squamous cell cancer (SCC) adjacent grossly normal-appearing uninvolved bronchial mucosa (from which SCC developed also "at risk" developing SCC) lung 12 subjects to determine involvement these vitamins 1) carcinogenesis 2) global DNA methylation. The were significantly lower SCCs than tissues (p = 0.03). 0.02). radiolabeled methyl incorporation (inversely related degree vivo methylation) was higher < 0.0001). correlation between inverse statistically significant ...
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