Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy

摘要: Several studies have implicated the involvement of poor glycemic control and oxidative/nitrosative stress in development diabetic neuropathic pain, an important microvascular complication affecting more than 50% patients. However, lack understanding underlying etiology, tolerance, inadequate relief possible toxicity associated with classical analgesics warrant investigation novel agents. Therefore, present study was carried out to investigate effect oryzanol (OZ), a commercially-important potent antioxidant component isolated from crude rice bran oil (cRBO), streptozotocin (STZ)-induced neuropathy rats. After eight weeks, rats developed which evident decreased tail-flick latency (thermal hyperalgesia) increased nociceptive behavior during formalin test. This accompanied by motor coordination based on evaluation neuromuscular strength. Na+ K+ ATPase, biochemical marker neuropathy, significantly inhibited sciatic nerve animals. The activities enzymes lipid peroxidation levels were elevated rats, indicating oxidative neuropathy. Chronic treatment (OZ) (50 100 mg/kg) per oral (p.o.) standard drug glibenclamide (Gl) (10 mg/kg, p.o.) attenuated behavioral as well changes findings provide experimental evidence protective effects OZ hyperglycemia-induced thermal hyperalgesia might be responsible for diabetes induced damage.