Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death

摘要: Although the role of autophagy in tumorigenesis remains controversial, recent reports support notion that inhibition promotes tumor formation. Damage-regulated regulator (DRAM) has been identified as an effector molecule is critical for p53-mediated apoptosis, and we investigated whether there might be other DRAM-like molecules linking apoptosis. In this study, cloned a novel DRAM-homologous protein, DRAM2, showed expression DRAM2 down-regulated ovarian tumors. mainly localized lysosome, co-localizes with DRAM. While DRAM or individually did not induce cell death, co-expression significantly induced while silencing endogenous attenuated suggesting involved death. Thus, propose reduced may contribute to enhanced survival cells.