Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer

摘要: Autophagy is a lysosomal-driven catabolic process that contributes to the preservation of cell homeostasis through regular elimination cellular damaged, aged, and redundant molecules organelles. plays dual opposite roles in cancer: on one hand it prevents carcinogenesis; other confers an advantage cancer cells survive under prohibitive conditions. has been implicated ovarian aggressiveness chemoresistance dormancy. Small noncoding microRNAs (miRNAs) regulate gene expression at posttranscriptional level, thus playing important role many aspects pathophysiology, including cancerogenesis progression. Certain miRNAs have recently emerged as epigenetic modulators autophagy cells. The mRNA several autophagy-related genes contains, fact, target sequence for belonging different families, with either oncosuppressive or oncogenic activities. MiRNA profiling studies identified some aberrantly expressed tissues can impact autophagy. In addition, plasma stroma cell-derived tumour-bearing patients relevant present review focuses potential implications regulating pathogenesis