Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.

作者： H. Jendralla , E. Baader , W. Bartmann , G. Beck , A. Bergmann

关键词: Stereochemistry 、 In vivo 、 Chemistry 、 HMG-CoA reductase 、 Biological activity 、 Stereoselectivity 、 Diol 、 Enzyme inhibitor 、 Heptanoic acid 、 Reductase

摘要: A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)- enoates (-heptanoates) 1 and 2 have been prepared tested for inhibiti 3-hydroxy-3-methylglutaryl-coenzyme reductase. The most potent compounds exceeded mevinolin's activity in vitro vivo.

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Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.

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Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.

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