Evaluation of a new erosion score by musculoskeletal ultrasound in patients with rheumatoid arthritis

摘要: The objectives of this study are to evaluate a new semi-quantitative (0–5) musculoskeletal ultrasound (US) erosion score in patients with rheumatoid arthritis (RA) and prove its usefulness the detection disease activity success therapy. Thirty-eight RA (mean duration 10.1 ± 11.9 years) were enrolled. Start or change therapy (DMARD/biologics) was an inclusion criterion. DAS28, laboratory (ESR CRP) US data evaluated before initiation after 1, 3, 6 12 months. Thirteen joints clinically more affected hand forefoot (wrist MCP, PIP, MTP 2–5) analyzed for synovitis grayscale (GS) power Doppler (PD) US, tenosynovitis/paratenonitis GS/PDUS (wrist, MCP level) erosions. Erosions by (grade 0, no erosion; grade 3 mm; 5, multiple bone erosions). After 12 months, DAS28 decreased from 4.5 3.4 (p < 0.001), GSUS 26.3 12.8 (p = 0.001) PDUS 10.6 4.1 (p < 0.001). 21.5 18.1 (p = 0.046). There longitudinal significant correlations between both (r = 0.368; p = 0.025) (r = 0.365; p = 0.026) over 1-year follow-up period. might be useful tool evaluation erosive changes patients. In course DMARD biologic therapy, it responsive under examination.