Risk factors for cervical precancer detection among previously unscreened HIV-infected women in Western Kenya.

摘要: HIV and cervical cancer are intersecting epidemics in many low-resource settings, yet there few accurate estimates of the scope this public health challenge. To understand disease prevalence risk factors for intraepithelial neoplasia 2 or greater (CIN2+), we conducted a cross-sectional study women undergoing screening as part routine care Kisumu, Kenya. Women were offered with visual inspection acetic acid, followed by confirmation colposcopy biopsy needed. Univariable multivariable analyses carried out to determine clinical demographic predictors prevalent CIN2+. Among 3,241 screened, 287 (9%) had an initial diagnosis biopsy-confirmed On analysis, combined oral contraceptives remained significantly associated detection CIN2+ among on HAART (AOR 1.84, CI 1.20–2.82), not 1.72, 95% 1.08–2.73), while use progesterone implant was increased 9.43, 2.85–31.20) only HAART. CD4+ nadir over 500 cells/mm3 reduced 0.61, 0.38, 0.97) overall group, but current 0.42, 0.22, 0.80). In conclusion, history less severe immunosuppression appeared reduce detection, count significant non-HAART users. The association hormonal contraception should be explored more prospective studies designed better control confounding factors.