Folate Levels in Pregnancy and Offspring Food Allergy and Eczema

摘要: Background High folate status in pregnancy has been implicated the increased prevalence of allergic disease, but there are no published data relating directly measured to challenge-proven food allergy among offspring. The study aim was examine association between red blood cell (RBC) trimester three and disease Methods Red levels were at 28-32 weeks' gestation a prospective birth cohort (n = 1074). Food outcomes assessed 1-year-old infants by skin prick testing subsequent challenge. Eczema questionnaire clinical review. RBC defined as greater than (>) 1360 nmol/L. Binomial regression used associations outcomes, adjusting for potential confounders. Results 88% (894/1064) pregnant women. mean concentration 1695.6 nmol/L (standard deviation 415.4) with 82% (731/894) >1360 There evidence either linear or non-linear relationships nor high (adjusted risk ratio (aRR) 2.89, 95% CI 0.90-9.35), sensitization (aRR 1.72, 0.85-3.49), eczema 0.97, 0.67-1.38). Conclusion majority women this had levels. allergy, sensitization, offspring, although larger studies required.