Separation of Enantiomers and Control of Elution Order of β-Lactams by GC Using Cyclodextrin-Based Chiral Stationary Phases
作者： Ke Huang , Daniel W. Armstrong , Eniko Forro , Ferenc Fulop , Antal Peter
DOI: 10.1365/S10337-008-0888-8
关键词: Bicyclic molecule 、 Inclusion compound 、 Mass spectrometry 、 Cyclodextrin 、 Organic chemistry 、 Chromatography 、 Enantiomer 、 Elution 、 Gas chromatography 、 Chemistry 、 Flame ionization detector 、 Analytical chemistry 、 Clinical biochemistry 、 Biochemistry
摘要: Enantiomers of 19 racemic β-lactams, with 3 and 4-position substitutions, were separated using gas chromatography. Excellent results achieved on derivatized cyclodextrin-based GC chiral stationary phases (CSPs). All compounds baseline separated, most high resolution factors. The Chiraldex G-TA was found to be the powerful CSP broadest enantioselectivity, while B-DM produced fastest separations for assayed. Results obtained in this work suggest that can serve as a potential method enantiomeric separation sufficiently volatile solid β-lactams.
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