Direct high-performance liquid chromatographic enantioseparation of β-lactam stereoisomers
作者： Antal Péter , Anita Árki , Enikő Forró , Ferenc Fülöp , Daniel W Armstrong
DOI: 10.1002/CHIR.20149
关键词:
摘要: High-performance liquid chromatographic methods were developed for the separation of enantiomers 12 beta-lactams. Direct separations performed on chiral stationary phases (CSPs) containing cellulose-tris-3,5-dimethylphenyl carbamate (Chiralcel OD-RH and OD-H columns), macrocyclic glycopeptide antibiotic teicoplanin (Chirobiotic T column), or aglycone TAG column) as selector. It was clearly established that, with teicoplanin-based columns, most often responsible enantioseparation The difference in enantioselective free energy between CSP range 0.02 0.97 kJ mol(-1) these beta-lactam stereoisomer separations. carried out high selectivity resolution, method therefore suitable monitoring enantiomeric excess after synthesis. Chirobiotic Chiralcel columns appear to be highly complementary one another. best this class compound could obtained using polar-organic mode plus normal-phase mode. elution sequence also determined.
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