High-Performance Liquid Chromatographic Separation of Stereoisomers of β -Amino Acids and a Comparison of Separation Efficiencies on Chirobiotic T and TAG Columns
作者： A Arki , D Tourwe , M Solymar , F Fueloep , DW Armstrong
DOI: 10.1365/S10337-004-0195-Y
关键词:
摘要: Direct and indirect reversed-phase high-performance liquid chromatographic methods were developed for the separation of enantiomers seventeen unnatural β-amino acids, including several β-3-homo amino acids. The direct separations underivatized analytes performed on chiral stationary phases containing macrocyclic glycopeptide antibiotic teicoplanin (Chirobiotic T column) aglycone TAG column). method involved pre-column derivatization with two new derivatizing agents, (1S,2S)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate, (S,S)-DANI (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester, (S)-NIFE. different compared in systematic examinations. effects organic modifier, mobile phase composition, pH flow rate investigated.
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