Pathological Mineralization: The Potential of Mineralomics

摘要: Pathological mineralization has been reported countless times in the literature and is a well-known phenomenon medical field for its connections to wide range of diseases, including cancer, cardiovascular, neurodegenerative diseases. The minerals involved calcification, however, have not directly studied as extensively organic components each pathologies. These isolation and, most them, physicochemical properties are hitherto fully known. In parallel development, materials science methods such electron microscopy, spectroscopy, thermal analysis, others used biology mainly study hard tissues biomaterials only recently incorporated other biological systems. This review connects soft tissue breast age-related macular degeneration, aortic valve stenosis, kidney stone Fahr’s syndrome, all which associated with processes. Furthermore, it describes how material characterization provide new information on Here, we focus diseases that calcium-composed discuss understanding these can insights their origins, considering different conditions features required type mineral be formed. We show mineralomics, or roles minerals, will help improve prevention against pathological build-up, cases mentioned this review, ultimately lead treatment Importantly, aims highlight chemical composition alone cannot support conclusions drawn nature minerals.