RAS Genes and Cancer
作者： Tikvah K. Hayes , Jeran K. Stratford , Andrea Wang-Gillam , Channing J. Der
DOI: 10.1007/978-3-7091-1806-1_7
关键词: Neuroblastoma RAS viral oncogene homolog 、 Cancer 、 Cancer research 、 Oncology 、 HRAS 、 Biology 、 Internal medicine 、 Mutation 、 Pancreatic cancer 、 GTPase 、 KRAS 、 Oncogene
摘要: The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. encode highly related small GTPases that are key regulators of cytoplasmic signaling networks include Raf-MEK-ERK mitogen-activated protein kinase cascade PI3K-Akt cascade. There is increasing evidence all mutations “not created equal” mutation specific therapies may be needed, there will not a “one size fits all” anti-Ras therapy. In this chapter, we summarize frequency nature cancers, with focus on two cancers highest mutations, pancreatic ductal adenocarcinoma (95 %), colorectal (40 %) cancers.
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