Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry
作者： Anton Kaufmann , Patrick Butcher , Kathryn Maden , Mirjam Widmer
DOI: 10.1016/J.CHROMA.2008.03.089
关键词: Electrospray 、 Analyte 、 Liquid–liquid extraction 、 Time-of-flight mass spectrometry 、 Chromatography 、 Sample preparation 、 Chemistry 、 Mass spectrometry 、 Solid phase extraction 、 Analytical chemistry 、 High-performance liquid chromatography
摘要: Abstract A quantitative multiresidue method covering more than 100 veterinary drugs, belonging to different drug families, has been developed. The proposed approach uses an liquid–liquid–solid extraction technique (bi-polarity extraction) which is capable in recovering polar, medium polar and apolar compounds. thorough generic reversed phase solid-phase (SPE) clean-up removes interfering proteins provides clean stable extracts. Dedicated rinsing steps are reduce analyte adsorption on glass walls precipitating proteins. resulting extract analyzed by ultra-performance liquid chromatography (UPLC) coupled time of flight mass spectrometry (TOF). was validated according the Commission Decision 2002/657/EEC. Validation coved relevant meat matrices (muscle, kidney liver).
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