Multicomponent reactions as a potent tool for the synthesis of benzodiazepines

摘要: Benzodiazepines (BZDs), a diverse class of benzofused seven-membered N-heterocycles, display essential pharmacological properties and play vital roles in some biochemical processes. They have mainly been prescribed as potential therapeutic agents, which interestingly represent various biological activities such anticancer, anxiolytic, antipsychotic, anticonvulsant, antituberculosis, muscle relaxant, antimicrobial activities. The extensive BZDs fields encouraged medicinal chemists to discover design novel BZD-based scaffolds candidates with the favorite activity through an efficient protocol. Although certainly valuable important, conventional synthetic routes these bicyclic benzene compounds contain methodologies often requiring multistep procedures, suffer from waste materials generation lack sustainability. By contrast, multicomponent reactions (MCRs) recently advanced green strategy for synthesizing desired scope. In this regard, MCRs, especially Ugi Ugi-type reactions, efficiently conveniently supply complex synthons, can easily be converted via suitable post-transformations. Also, Mannich-type provide speedy economic approaches one-pot one-step synthesis BZDs. As result, functionalized-BZDs achieved by developing mild, efficient, high-yielding MCR protocols. This review covers all aspects particular focus on MCRs well mechanism chemistry present manuscript opens new avenue organic, medicinal, industrial safe, environmentally benign, economical methods known