Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones
作者： Nikolas Tim Martin , John Cameron Bell
DOI: 10.1016/J.YMTHE.2018.04.001
关键词: Bioinformatics 、 Cancer biology 、 Oncolytic virus 、 Combination therapy 、 Medicine 、 Cancer 、 Virus
摘要: Over the last 60 years an eclectic collection of microbes has been tested in a variety pre-clinical models as anti-cancer agents. At forefront this research are number virus-based platforms that have shown exciting activity and collectively referred to oncolytic viruses. Our true understanding potential limitations therapeutic modality substantially advanced through clinical studies carried out over 25 years. Perhaps not surprising, with all other cancer therapeutics, it become clear current virus therapeutics on their own unlikely be effective majority patients. The greatest gains will therefore made through thoughtful combination strategies built upon biology.
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