Targeting Tumors with Salmonella Typhimurium- Potential for Therapy

摘要: Received: December 23, 2010 , Accepted: 29, Published: January 3, // When one considers the organism Salmonella enterica serotype Typhimurium (S. Typhimurium), usually thinks of Gram-negative enteric pathogen that causes severe food borne illness, gastroentertitis. In this context, idea being exploited as a cancer therapeutic seems pretty remote. However, there has been an escalating interest in development tumor-therapeutic bacteria for use treatment variety cancers. This strategy takes advantage remarkable ability certain to preferentially replicate and accumulate within tumors. case S. Typhimurium, infects selectively grows implanted tumors, achieving tumor/normal tissue ratios approximately 1,000:1. also some attractive properties well suited design chemotherapeutic agent. particular, can easily be manipulated carry foreign genes, since species is facultative anaerobe, it able survival both oxygenated hypoxic conditions, implying could colonize small metastatic lesions larger These observations are impetus burgeoning field focused on clinically useful anti-cancer We will discuss three cutting edge technologies employing target