Tissue hyaluronan expression, as reflected in the sputum of lung cancer patients, is an indicator of malignancy

摘要: Hyaluronan (HA) shows promise for detecting cancerous change in pleural effusion and urine. However, there is uncertainty about the localization of HA tumor tissue its relationship with different histological types other components extracellular matrix, such as angiogenesis. We evaluated association between degree malignancy through expression lung sputum. Tumoral had significantly increased compared to normal tissue. Strong staining intensity associated cancer cells was significant squamous cell carcinoma adenocarcinoma large carcinoma. A direct found tumors a high percentage MVD (microvessel density) tumoral stroma. Similarly N1 levels cells. Cox multivariate analysis showed better survival low HA. sputum from patients cancer-free healthy volunteers correlation Localization related reflected sputum, making this an emerging factor important diagnostic procedure suspected have cancer. Further study additional randomized prospective trial required finalize these results validate our quantitative assessment HA, well couple it gold standard cytology.