Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation
作者： M A Dentener
关键词: Lung 、 Pneumonia 、 Immunology 、 Proinflammatory cytokine 、 Respiratory disease 、 Sputum 、 Population 、 COPD 、 Medicine 、 Inflammation
摘要: Background: Chronic inflammation and airway remodelling are characteristics of chronic obstructive pulmonary disease (COPD). Hyaluronan (HA) is an extracellular matrix compound with proinflammatory activity. HA levels in induced sputum from patients COPD were measured related to local inflammation. The expression hyaluronan synthase 2 (HAS2) hyaluronidase (HYAL2) was analysed lung tissue. Methods: Sputum obtained 18 (forced expiratory volume 1 second (FEV ) 62% predicted (range 20–76)) 14 healthy smokers. inflammatory markers using ELISA assays. Lung sections five severe Results: significantly higher the than controls. population appeared consist two subpopulations either high or moderate levels. subgroup had lower FEV group. In addition, neutrophil influx interleukin-8, soluble tumour necrosis factor receptors R55 R75 those Semiquantitative analysis revealed enhanced HYAL2 tissue compared control subjects. Conclusion: These data indicate a relationship between levels, severity disease, suggest breakdown lungs COPD.
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N. MILMAN, M. S. KRISTENSEN, K. BENTSEN, Hyaluronan and procollagen type III aminoterminal peptide in serum and bronchoalveolar lavage fluid from patients with pulmonary fibrosis. Apmis. ,vol. 103, pp. 749- 754 ,(1995) , 10.1111/J.1699-0463.1995.TB01433.X
Warren Knudson, Geraldine Chow, Cheryl B Knudson, CD44-mediated uptake and degradation of hyaluronan Matrix Biology. ,vol. 21, pp. 15- 23 ,(2002) , 10.1016/S0945-053X(01)00186-X
Amanda J. Fosang, Nina J. Hey, Stephen L. Carney, Timothy E. Hardinghami, An ELISA plate-based assay for hyaluronan using biotinylated proteoglycan G1 domain (HA-binding region). Matrix. ,vol. 10, pp. 306- 313 ,(1990) , 10.1016/S0934-8832(11)80186-1
P.J. Barnes, S.D. Shapiro, R.A. Pauwels, Chronic obstructive pulmonary disease: molecular and cellular mechanisms. European Respiratory Journal. ,vol. 22, pp. 672- 688 ,(2003) , 10.1183/09031936.03.00040703
Yuichi Ohkawara, Gen Tamura, Tadashi Iwasaki, Akiko Tanaka, Tadashi Kikuchi, Kunio Shirato, Activation and Transforming Growth Factor- β Production in Eosinophils by Hyaluronan American Journal of Respiratory Cell and Molecular Biology. ,vol. 23, pp. 444- 451 ,(2000) , 10.1165/AJRCMB.23.4.3875
Juanita H. Vernooy, Mehmet Küçükaycan, Jan A. Jacobs, Niels H. Chavannes, Wim A. Buurman, Mieke A. Dentener, Emiel F. Wouters, Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. American Journal of Respiratory and Critical Care Medicine. ,vol. 166, pp. 1218- 1224 ,(2002) , 10.1164/RCCM.2202023
T C O'Shaughnessy, T W Ansari, N C Barnes, P K Jeffery, Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 852- 857 ,(1997) , 10.1164/AJRCCM.155.3.9117016
Jørgen Vestbo, Suzanne S. Hurd, Alvar G. Agustí, Paul W. Jones, Claus Vogelmeier, Antonio Anzueto, Peter J. Barnes, Leonardo M. Fabbri, Fernando J. Martinez, Masaharu Nishimura, Robert A. Stockley, Don D. Sin, Roberto Rodriguez-Roisin, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. ,vol. 187, pp. 347- 365 ,(2013) , 10.1164/RCCM.201204-0596PP
Christian C. Termeer, Jörn Hennies, Ursula Voith, Thomas Ahrens, Johannes M. Weiss, Peter Prehm, Jan C. Simon, Oligosaccharides of Hyaluronan Are Potent Activators of Dendritic Cells The Journal of Immunology. ,vol. 165, pp. 1863- 1870 ,(2000) , 10.4049/JIMMUNOL.165.4.1863
B F Haynes, M C Levesque, CYTOKINE INDUCTION OF THE ABILITY OF HUMAN MONOCYTE CD44 TO BIND HYALURONAN IS MEDIATED PRIMARILY BY TNF-ALPHA AND IS INHIBITED BY IL-4 AND IL-13 Journal of Immunology. ,vol. 159, pp. 6184- 6194 ,(1997)