Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications

作者: Viviana Galimberti , Elisa Vicini , Giovanni Corso , Consuelo Morigi , Sabrina Fontana

DOI: 10.1016/J.BREAST.2017.06.034

关键词: Breast reconstructionOncoplastic SurgeryMastectomySurgeryContraindicationMedicineNipple dischargeBreast cancerPlastic surgeryRadiation therapy

摘要: Skin-sparing (SSM) and nipple-sparing (NSM) mastectomies are relatively new conservative surgical approaches to breast cancer. In SSM most of the skin is conserved create a pocket that facilitates immediate reconstruction with implant or autologous graft achieve quality cosmetic outcome. NSM closely similar except nipple-areola complex (NAC) also conserved. Meta-analyses indicate outcomes for do not differ from those non-conservative mastectomies. Recurrence rates in NAC after acceptably low (0-3.7%). Other studies associated high patient satisfaction good psychological adjustment. Indications carcinoma DCIS require mastectomy (including neoadjuvant chemotherapy). suitable women undergoing risk-reducing bilateral mastectomy. Tumor less than 2 cm recommended, but may be important no evidence nipple involvement on mandatory intraoperative margin assessment. A positive an absolute contraindication preservation. contraindications microcalcifications close subareolar region discharge. Complication other types post-mastectomy reconstructions. The main complication necrosis, however as surgeon experience matures, frequency declines. Factors complications voluminous breast, ptosis, smoking, obesity, radiotherapy. Since access incision small, tissue left behind, so only experienced surgeons should these operations collaboration plastic surgeon. For cancer patients requiring mastectomy, option choice.

参考文章(21)
A. T. Manning, C. Wood, A. Eaton, M. Stempel, D. Capko, A. Pusic, M. Morrow, V. Sacchini, Nipple-sparing mastectomy in patients with BRCA1/2 mutations and variants of uncertain significance. British Journal of Surgery. ,vol. 102, pp. 1354- 1359 ,(2015) , 10.1002/BJS.9884
Umberto Veronesi, Giuseppe Viale, Giovanni Paganelli, Stefano Zurrida, Alberto Luini, Viviana Galimberti, Paolo Veronesi, Mattia Intra, Patrick Maisonneuve, Francesca Zucca, Giovanna Gatti, Giovanni Mazzarol, Concetta De Cicco, Dario Vezzoli, Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Annals of Surgery. ,vol. 251, pp. 595- 600 ,(2010) , 10.1097/SLA.0B013E3181C0E92A
M. Rietjens, C.A. Urban, P.C. Rey, G. Mazzarol, P. Maisonneuve, C. Garusi, M. Intra, S. Yamaguchi, N. Kaur, F. De Lorenzi, A.G.Z. Matthes, S. Zurrida, J.Y. Petit, Long-term oncological results of breast conservative treatment with oncoplastic surgery The Breast. ,vol. 16, pp. 387- 395 ,(2007) , 10.1016/J.BREAST.2007.01.008
Victorien M.T. van Verschuer, Marc A.M. Mureau, Jessica P. Gopie, Elvira L. Vos, Cornelis Verhoef, Marian B.E. Menke-Pluijmers, Linetta B. Koppert, Patient Satisfaction and Nipple-Areola Sensitivity After Bilateral Prophylactic Mastectomy and Immediate Implant Breast Reconstruction in a High Breast Cancer Risk Population: Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy. Annals of Plastic Surgery. ,vol. 77, pp. 145- 152 ,(2016) , 10.1097/SAP.0000000000000366
Sophocles Lanitis, Paris P. Tekkis, George Sgourakis, Nikitas Dimopoulos, Ragheed Al Mufti, Dimitri J. Hadjiminas, Comparison of Skin-Sparing Mastectomy Versus Non–Skin-Sparing Mastectomy for Breast Cancer Annals of Surgery. ,vol. 251, pp. 632- 639 ,(2010) , 10.1097/SLA.0B013E3181D35BF8
Katharine Yao, Erik Liederbach, Rong Tang, Lan Lei, Tomasz Czechura, Mark Sisco, Michael Howard, Peter J. Hulick, David J. Winchester, Suzanne B. Coopey, Barbara L. Smith, Nipple-Sparing Mastectomy in BRCA1/2 Mutation Carriers: An Interim Analysis and Review of the Literature Annals of Surgical Oncology. ,vol. 22, pp. 370- 376 ,(2014) , 10.1245/S10434-014-3883-3
Jessica Gahm, Per Hansson, Yvonne Brandberg, Marie Wickman, Breast sensibility after bilateral risk-reducing mastectomy and immediate breast reconstruction: A prospective study☆ Journal of Plastic Reconstructive and Aesthetic Surgery. ,vol. 66, pp. 1521- 1527 ,(2013) , 10.1016/J.BJPS.2013.06.054
Mark A. Jabor, Payam Shayani, Donald R. Collins, Tomer Karas, Benjamin E. Cohen, Nipple-areola reconstruction: satisfaction and clinical determinants. Plastic and Reconstructive Surgery. ,vol. 110, pp. 457- 463 ,(2002) , 10.1097/00006534-200208000-00013
Visnu Lohsiriwat, Nicole Rotmensz, Edoardo Botteri, Mattia Intra, Paolo Veronesi, Stefano Martella, Cristina Garusi, Francesca De Lorenzi, Andrea Manconi, Giuseppe Lomeo, Mario Rietjens, Mario Schorr, Maximiliano Cassilha Kneubil, Jean Yves Petit, Do clinicopathological features of the cancer patient relate with nipple areolar complex necrosis in nipple-sparing mastectomy? Annals of Surgical Oncology. ,vol. 20, pp. 990- 996 ,(2013) , 10.1245/S10434-012-2677-8