Pigmentary Traits, Ethnic Origin, Benign Nevi, and Family History as Risk Factors for Cutaneous Malignant Melanoma

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DOI: 10.1093/JNCI/72.2.257

关键词: MelanomaOdds ratioRelative riskMedicineDermatologyEye colorRisk factorNevusFamily historyEthnic origin

摘要: The roles of constitutional factors and benign nevi in causation malignant melanoma were examined a case-control study 511 patients matched controls Western Australia. strongest risk factor was the number palpable on subject's arms. Compared to melanomas for persons having no arms, relative 2.0 with 1-4 nevi, 4.0 5-9 11.3 10 or more (P less than .0001). Of several pigmentary traits known have associations melanoma, inability tan most important. Susceptibility sunburn hair color also had significant effects that independent tanning ability; however, after these controlled, measured skin eye additional effects. A reduced observed two Southern European grandparents [odds ratio (OR) = 0.39; P .025]. Persons Celtic origin did not significantly increased (OR 1.18). Possession one affected blood relatives related an 2.69; traits, ethnic origin, family history as largely another.

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