MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer.
作者： Nana Li , Yuan Miao , Yujia Shan , Bing Liu , Yang Li
关键词: microRNA 、 Downregulation and upregulation 、 Kinase 、 PI3K/AKT/mTOR pathway 、 Cell 、 PTEN 、 Carcinogenesis 、 Biology 、 Breast cancer 、 Cancer research
摘要: Accumulating evidences have revealed that dysregulated microRNAs (miRNAs) involve in the tumorigenesis, progression and even lead to poor prognosis of various carcinomas, including breast cancer. MiRNA-106b-5p (miR-106b) miRNA-93-5p (miR-93) levels were confirmed be significantly upregulated cancer clinical samples (n=36) metastatic cell line (MDA-MB-231) compared with those paired adjacent tissues normal epithelial (MCF-10A). Moreover, further research stated capability migration, invasion proliferation changed along altered expression miR-106b miR-93 PTEN, tumor-suppressor gene, was discovered reduced or MDA-MB-231 cells high miR-93, which inversely expressed PTEN overexpression cells. Based on investigation, induced simultaneously enhanced activity phosphatidylinositol-3 kinase (PI3K)/Akt pathway MCF-7 cells, could blocked by upregulation PTEN. Furthermore, suppression reversed function anti-miR-106b anti-miR-93 indicating directly targeted these miRNAs acted as potential therapeutic target for therapy. In short, reductive mediated promoted through PI3K/Akt
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