miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression
作者： Nahyun Choi , Jongmin Park , Jeon-Soo Lee , Jeehyun Yoe , Guk Yeol Park
关键词: Carcinoma 、 Cell growth 、 Cancer 、 Immunology 、 Mir-375 、 RNA interference 、 Cancer research 、 Prostate cancer 、 Medicine 、 LNCaP 、 microRNA 、 Oncology
摘要: // Nahyun Choi 1 , Jongmin Park Jeon-Soo Lee Jeehyun Yoe Guk Yeol Eunjeong Kim Hyeongrin Jeon 2 Yong Mee Cho 3 Tae-Young Roh 1,2 and Yoontae Department of Life Sciences, Pohang University Science Technology, Pohang, Kyungbuk, Republic Korea Division Integrative Bioscience Biotechnology, Pathology, Ulsan College Medicine, Asan Medical Center, Seoul, Correspondence to: Lee, email: Keywords : prostate cancer, capicua, ETV5, CRABP1, microRNA Received March 30, 2015 Accepted May Published June 08, Abstract Capicua (CIC) has been implicated in pathogenesis spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease some types cancer; however, the role CIC cancer remains unknown. Here we show that suppresses progression. expression was markedly decreased human prostatic carcinoma. overexpression suppressed cell proliferation, invasion, migration, whereas RNAi exerted opposite effects. We found knock-down derepresses ETV5 CRABP1 LNCaP PC-3 cells, respectively, thereby promoting proliferation invasion. also discovered miR-93, miR-106b, miR-375, which are known to be frequently overexpressed patients, cooperatively down-regulate levels promote Altogether, suggest miR-93/miR-106b/miR-375-CIC-CRABP1 as a novel key regulatory axis
postech.ac.kr参考文章(38)
Natasza A. Kurpios, Nancy A. Sabolic, Trevor G. Shepherd, Gina M. Fidalgo, John A. Hassell, Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. Journal of Mammary Gland Biology and Neoplasia. ,vol. 8, pp. 177- 190 ,(2003) , 10.1023/A:1025948823955
Kati P. Porkka, Minja J. Pfeiffer, Kati K. Waltering, Robert L. Vessella, Teuvo L.J. Tammela, Tapio Visakorpi, MicroRNA Expression Profiling in Prostate Cancer Cancer Research. ,vol. 67, pp. 6130- 6135 ,(2007) , 10.1158/0008-5472.CAN-07-0533
Jeremy P. Clark, Colin S. Cooper, ETS gene fusions in prostate cancer Nature Reviews Urology. ,vol. 6, pp. 429- 439 ,(2009) , 10.1038/NRUROL.2009.127
Zhengyan Kan, Bijay S. Jaiswal, Jeremy Stinson, Vasantharajan Janakiraman, Deepali Bhatt, Howard M. Stern, Peng Yue, Peter M. Haverty, Richard Bourgon, Jianbiao Zheng, Martin Moorhead, Subhra Chaudhuri, Lynn P. Tomsho, Brock A. Peters, Kanan Pujara, Shaun Cordes, David P. Davis, Victoria E. H. Carlton, Wenlin Yuan, Li Li, Weiru Wang, Charles Eigenbrot, Joshua S. Kaminker, David A. Eberhard, Paul Waring, Stephan C. Schuster, Zora Modrusan, Zemin Zhang, David Stokoe, Frederic J. de Sauvage, Malek Faham, Somasekar Seshagiri, Diverse somatic mutation patterns and pathway alterations in human cancers Nature. ,vol. 466, pp. 869- 873 ,(2010) , 10.1038/NATURE09208
Lihua Julie Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo Selase Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, Michael H. Brodsky, FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system Nucleic Acids Research. ,vol. 39, pp. 111- 117 ,(2011) , 10.1093/NAR/GKQ858
Glen Kristiansen, Klaus Jung, Annika Schaefer, Monika Jung, Hans-Joachim Mollenkopf, Ina Wagner, Carsten Stephan, Florian Jentzmik, Kurt Miller, Michael Lein, Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. International Journal of Cancer. ,vol. 126, pp. 1166- 1176 ,(2009) , 10.1002/IJC.24827
Diane Dong, Sarah E. Ruuska, David J. Levinthal, Noa Noy, Distinct roles for cellular retinoic acid-binding proteins I and II in regulating signaling by retinoic acid. Journal of Biological Chemistry. ,vol. 274, pp. 23695- 23698 ,(1999) , 10.1074/JBC.274.34.23695
Yoontae Lee, Rodney C Samaco, Jennifer R Gatchel, Christina Thaller, Harry T Orr, Huda Y Zoghbi, miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis Nature Neuroscience. ,vol. 11, pp. 1137- 1139 ,(2008) , 10.1038/NN.2183
Eunjeong Kim, Sungjun Park, Nahyun Choi, Jieon Lee, Jeehyun Yoe, Soeun Kim, Hoe-Yune Jung, Kyong-Tai Kim, Hyojin Kang, John D. Fryer, Huda Y. Zoghbi, Daehee Hwang, Yoontae Lee, Deficiency of Capicua disrupts bile acid homeostasis Scientific Reports. ,vol. 5, pp. 8272- 8272 ,(2015) , 10.1038/SREP08272
Agustí Alentorn, Marc Sanson, Ahmed Idbaih, Oligodendrogliomas: new insights from the genetics and perspectives. Current Opinion in Oncology. ,vol. 24, pp. 687- 693 ,(2012) , 10.1097/CCO.0B013E328357F4EA