miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1
作者： Yuan Wang , Rachel Lieberman , Jing Pan , Qi Zhang , Meijun Du
DOI: 10.1186/S12943-016-0556-9
关键词: Docetaxel resistance 、 Prostate cancer 、 Oncology 、 Internal medicine 、 Docetaxel 、 YAP1 、 SEC23A 、 Mir-375 、 Drug resistance 、 Chemotherapy 、 Biology
摘要: Background Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were significantly associated with poor overall survival of mCRPC patients. In this study, we evaluated if induced chemo-resistance to docetaxel through regulating target genes drug resistance.
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