miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
作者： Yoontae Lee , Rodney C Samaco , Jennifer R Gatchel , Christina Thaller , Harry T Orr
DOI: 10.1038/NN.2183
关键词:
摘要: Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level the polyglutamine-expanded protein one factors that contributes to disease severity. Here we found miR-19, miR-101 and miR-130 co-regulate levels their inhibition enhanced cytotoxicity ATXN1 human cells. We provide new candidate mechanism for modulating pathogenesis neurodegenerative diseases sensitive dosage.
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