An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine.
作者： Dimitrios Psachoulias , Maria Vertzoni , James Butler , David Busby , Moira Symillides
DOI: 10.1007/S11095-012-0844-Z
关键词: Small intestine 、 Pharmacology toxicology 、 Solubility 、 In vitro 、 Chemistry 、 Urea metabolism 、 Chromatography 、 Intestinal absorption
摘要: Purpose To develop an in vitro methodology for prediction of concentrations and potential precipitation highly permeable, lipophilic weak bases fasted upper small intestine based on ketoconazole dipyridamole luminal data. Evaluate usefulness predicting AZD0865 SB705498 plasma
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