Comparison of rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using γ scintigraphy

作者: Kilian Kelly , Bridget O'Mahony , Blythe Lindsay , Tamara Jones , Tim J. Grattan

DOI: 10.1023/A:1026155822121

关键词:

摘要: Purpose. To investigate the hypothesis that faster drug absorption from a new paracetamol formulation containing sodium bicarbonate compared to conventional results combination of enhanced gastric emptying and disintegration/dissolution.

参考文章(15)
Jasper Dingemanse, Martine Clozel, Paul L. M. Van Giersbergen, Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects. British Journal of Clinical Pharmacology. ,vol. 53, pp. 355- 362 ,(2002) , 10.1046/J.1365-2125.2002.01158.X
Arnold Wald, David H. Van Thiel, Leah Hoechstetter, Judith S. Gavaler, Kimberly M. Egler, Raymond Verm, Larry Scott, Roger Lester, Gastrointestinal transit the effect of the menstrual cycle Gastroenterology. ,vol. 80, pp. 1497- 1500 ,(1981) , 10.1016/0016-5085(81)90263-8
R. C. HEADING, J. NIMMO, L. F. PRESCOTT, P. TOTHILL, The dependence of paracetamol absorption on the rate of gastric emptying British Journal of Pharmacology. ,vol. 47, pp. 415- 421 ,(1973) , 10.1111/J.1476-5381.1973.TB08339.X
R. Khosla, S.S. Davis, Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects International Journal of Pharmaceutics. ,vol. 52, pp. 1- 10 ,(1989) , 10.1016/0378-5173(89)90082-3
L P Degen, S F Phillips, Variability of gastrointestinal transit in healthy women and men. Gut. ,vol. 39, pp. 299- 305 ,(1996) , 10.1136/GUT.39.2.299
Laurie F. Prescott, Paracetamol: past, present, and future. American Journal of Therapeutics. ,vol. 7, pp. 143- 148 ,(2000) , 10.1097/00045391-200007020-00011
J. N. Hunt, J. D. Pathak, The osmotic effects of some simple molecules and ions on gastric emptying. The Journal of Physiology. ,vol. 154, pp. 254- 269 ,(1960) , 10.1113/JPHYSIOL.1960.SP006577
G. Paintaud, P. Thibault, P.-E. Queneau, J. Magnette, M. Bérard, L. Rumbach, P. R. Bechtel, P. Carayon, Intraindividual variability of paracetamol absorption kinetics after a semi-solid meal in healthy volunteers European Journal of Clinical Pharmacology. ,vol. 53, pp. 355- 359 ,(1998) , 10.1007/S002280050393