Facile synthesis of near-infrared CuInS 2 /ZnS quantum dots and glycol-chitosan coating for in vivo imaging
作者： Eun-Mi Kim , Seok Tae Lim , Myung-Hee Sohn , Hwan-Jeong Jeong
DOI: 10.1007/S11051-017-3944-1
关键词: Photochemistry 、 Organic synthesis 、 Luminescence 、 Nanoparticle 、 Covalent bond 、 Semiconductor 、 Dynamic light scattering 、 Quantum dot 、 Crystal growth 、 Nanotechnology 、 Materials science
摘要: This study describes the synthesis method of water-soluble, low-toxicity, photostable highly luminescent probes based on I–III–VI2 type semiconductor quantum dots (QDs) and possibility tumor targeting in living animals. Cd-free high-quality CuInS2/ZnS core/shell QDs were synthesized, their surfaces reacted with mercaptoundecanoic acid for aqueous phase transfer followed by reaction glycol-chitosan; lastly, Arg-Gly-Asp (RGD) integrin-binding peptide was covalently attached vivo targeting. Dowtherm A, a viscous heat-transfer organic fluid, used to control crystal growth at high temperature (>230 °C) during synthesis. The structural optical properties resulting investigated. average diameters CuInS2 3.0 3.7 nm, respectively. Cell toxicity targetability RR1022 cancer cell-xenografted mice further evaluated using cRGDyk-tagged glycol-chitosan-coated QDs. Glycol-chitosan-coated MUA-QDs displayed Z-average diameter 203.8 ± 7.67 nm water dynamic light scattering.
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