Synthesis and evaluation of hydroponically alginate nanoparticles as novel carrier for intravenous delivery of propofol.
作者： Alireza Hassani Najafabadi , Saman Azodi-Deilami , Majid Abdouss , Hamid Payravand , Sina Farzaneh
DOI: 10.1007/S10856-015-5452-0
关键词:
摘要: Commercial lipid emulsion of propofol (CLE) has several drawbacks including pain on injection and instability. In this paper, a novel nanocarrier system is introduced to improve stability solubility the poorly soluble anesthetic drug, propofol, for intravenous administration. alginate modified using facile method in which carboxylic group grafted octanol. The octanol–grafted (Alg–C8) then employed prepare nanoparticles are subsequently used encapsulation propofol. analyzed their pH, osmolarity, particle size, stability, morphology sleep recovery results compared with CLE as control. It revealed that have average size 180 nm ± 1.2 spherical less than while osmolarity profile release formulated similar those CLE. addition, show good chemical physical storage at room temperature least 6 months animal test rats shows no significant difference time unconsciousness righting reflex between concluded encapsulated here could be promising clinical delivery study provides an efficient preparing carrier water insoluble drugs.
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