Structural effects on cosolubilization of dendrimer and propofol in water dilutable microemulsions as delivery vehicle

摘要: Abstract In this study we characterized a new and improved transport vehicle for 2,6-diisopropylphenol (propofol), hydrophobic anesthesia drug, in the absence presence of dendrimers being transporting agents across cells, polypropylenimine (PPI) dendrimer generation 2 (PPI-G2) into microemulsion (ME). Three unique systems water-dilutable compositions capable inverting from W/O to bicontinuous O/W structures upon water dilutions were studied by means electrical conductivity, electron paramagnetic resonance (EPR), self-diffusion nuclear magnetic (SD-NMR). The microviscosity, as well order parameter (from EPR results) increase with content, while ME. Inversion mesophase nanodroplets caused very minor parameter. Self-diffusion NMR measurements provided information on diffusivity interactions different components It was found that propofol has no effect since it is embedded within core ME droplets. However, increases water. addition, learned at high remains solubilized; however its location ME/water interface moves continuous phase. demonstrates ability dilutable MEs act drug carriers hosting both dendrimer.