Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep
作者： M. Carey Satterfield , Kathrin A. Dunlap , Duane H. Keisler , Fuller W. Bazer , Guoyao Wu
DOI: 10.1007/S00726-011-1168-8
关键词: Leptin 、 Brown adipose tissue 、 Intrauterine growth restriction 、 Endocrinology 、 Internal medicine 、 Fetus 、 Embryo transfer 、 Adipose tissue 、 Biology 、 Pregnancy 、 Gestation
摘要: Intrauterine growth restriction is a significant problem worldwide, resulting in increased rates of neonatal morbidity and mortality, as well risks for metabolic cardiovascular disease. The present study investigated the role maternal undernutrition l-arginine administration on fetal development. Embryo transfer was utilized to generate genetically similar singleton pregnancies. On Day 35 gestation, ewes were assigned receive either 50 or 100% their nutritional requirements. Ewes received i.v. injections saline three times daily from 100 125. Fetal assessed at necropsy Maternal dietary manipulation altered circulating concentrations leptin, progesterone, amino acids plasma. weight reduced nutrient-restricted 125 compared with fed ewes. Compared saline-treated underfed ewes, did not affect but pancreas by 32% peri-renal brown adipose tissue mass 48%. These results indicate that enhanced pancreatic postnatal effects warrant further study.
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