作者: Daniel F Veber , Ralph F Hirschmann , Iii Karl Pfister
DOI:
关键词: Glutathione 、 Dehydration 、 Acetic anhydride 、 Alpha (ethology) 、 Organic chemistry 、 Aspartic acid 、 Glycine 、 Sodium 、 Liquid ammonia 、 Chemistry
摘要: This disclosure describes the preparation of alpha -methyl glutathione and its aspartyl analog by reaction N-carbobenzoxy- glutamic or aspartic acid anhydrides with S-benzyl-cysteinyl glycine at a temperature about 0 DEG C. pH 11. The protecting groups are subsequently removed reduction sodium in liquid ammonia. dehydration substituted acids acetic anhydride dicyclohexylcarbodiimide is also described.