{60 -Methyl glutathione, analogs thereof, intermediates therefore and processes for their preparation

作者: Daniel F Veber , Ralph F Hirschmann , Iii Karl Pfister

DOI:

关键词: GlutathioneDehydrationAcetic anhydrideAlpha (ethology)Organic chemistryAspartic acidGlycineSodiumLiquid ammoniaChemistry

摘要: This disclosure describes the preparation of alpha -methyl glutathione and its aspartyl analog by reaction N-carbobenzoxy- glutamic or aspartic acid anhydrides with S-benzyl-cysteinyl glycine at a temperature about 0 DEG C. pH 11. The protecting groups are subsequently removed reduction sodium in liquid ammonia. dehydration substituted acids acetic anhydride dicyclohexylcarbodiimide is also described.

参考文章(1)
Amiard Gaston, Heymes Rene, Velluz Leon, Method of making glutathione ,(1956)