Chronic hypoventilation and development of brain stem gliosis.

摘要: Chronic hypoventilation is important in the pathogenesis of congenital syndromes and sudden infant death syndrome. Cases can be divided clinically into those with a defective respiratory drive mechanical impairment either lungs or chest wall. To determine relationship between chronic brain stem gliosis, development astrocytes normal abnormal cases type was studied morphometrically. The glial fibrillary acidic protein immunoperoxidase method staining showed transient increase some parts during early infancy thirty-five cases. astrocytosis even greater both types including subjects myopathy, Ondine's curse, Gliosis these may have resulted from "asphyxia" stem, as seen myopathies involving muscles. However, involvement centers suggest failure neural control that further compromises function.