Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome
作者： Toshimasa Obonai , Sachio Takashima , Laurence E. Becker , Masami Asanuma , Ryuzo Mizuta
DOI: 10.1016/S0887-8994(96)00217-2
关键词: Astrogliosis 、 Gliosis 、 Solitary nucleus 、 Substance P 、 Sudden death 、 Spinal trigeminal nucleus 、 Sudden infant death syndrome 、 Endocrinology 、 Biology 、 Glial fibrillary acidic protein 、 Internal medicine
摘要: Substance P and glial fibrillary acidic protein (GFAP) immunohistochemistry was applied to the medulla of neonatal infants who died sudden infant death syndrome (SIDS). A quantitative analysis cells demonstrating immunoreactivity GFAP substance in 15 SIDS cases revealed increased reticular formation, dorsal vagal nucleus, solitary nucleus an increase spinal trigeminal as compared with that age-matched controls. immunopositivity suggests astrogliosis which implies a pathologic insult neurons area astrogliosis. The failure these sites show enhanced may indirectly indicate altered neurons. Further study prenatal events be importance clarifying pathogenesis SIDS.
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