Recurrent aphthous ulcers in Fanconi's anaemia: a case report

作者: Feyza Otan , Gokhan Acikgoz , Umur Sakallioglu , Burcu Ozkan

DOI: 10.1111/J.1365-263X.2004.00549.X

关键词: Oral ulcerationsBlood transfusionSevere anaemiaSurgeryIncreased haemoglobinMedicineAphthous ulcerationsNeutropeniaDermatologyStomatitisFanconi's anaemia

摘要: Fanconi's anaemia (FA) is an autosomal recessive disorder that clinically characterized by aplastic anaemia, congenital malformations of the renal, cardiac, skeletal and skin structures, increased predisposition to malignancies. Patients with FA often present bleeding infection, which are symptoms related thrombocytopenia neutropenia. There few reports oral manifestations FA. We describe aphthous ulcerations in two siblings was a rapid improvement healing ulcers after blood transfusions haemoglobin levels. This may support role severe ulcerations.

参考文章(17)
SJ Knox, FD Wilson, BR Greenberg, M Shifrine, LS Rosenblatt, JD Reeves, H Misra, Increased radiosensitivity of a subpopulation ot T-lymphocyte progenitors from patients with Fanconi's anemia Blood. ,vol. 57, pp. 1043- 1048 ,(1981) , 10.1182/BLOOD.V57.6.1043.1043
MICHAEL SWIFT, Fanconi's anaemia in the genetics of neoplasia. Nature. ,vol. 230, pp. 370- 373 ,(1971) , 10.1038/230370A0
Blanche P. Alter, Fanconi's anemia. Current concepts. Journal of Pediatric Hematology Oncology. ,vol. 14, pp. 170- 176 ,(1992) , 10.1097/00043426-199205000-00014
B. P. Alter, FANCONI'S ANAEMIA AND ITS VARIABILITY British Journal of Haematology. ,vol. 85, pp. 9- 14 ,(1993) , 10.1111/J.1365-2141.1993.TB08638.X
Gregory Sarna, Peter Tomasulo, Michael J. Lotz, Joseph F. Bubinak, N. Raphael Shulman, Seymour Perry, Multiple neoplasms in two siblings with a variant form of Fanconi's anemia Cancer. ,vol. 36, pp. 1029- 1033 ,(1975) , 10.1002/1097-0142(197509)36:3<1029::AID-CNCR2820360328>3.0.CO;2-5
John D. Engel, James D. Ruskin, Harold K. Tu, Hematologic management of a patient with Fanconi's anemia undergoing bone grafting and implant surgery. Journal of Oral and Maxillofacial Surgery. ,vol. 50, pp. 288- 292 ,(1992) , 10.1016/0278-2391(92)90329-X
Gino R. Somers, Sepehr N. Tabrizi, Karin Tiedemann, Chung Wo Chow, Suzanne M. Garland, Deon J. Venter, Squamous Cell Carcinoma of the Tongue in a Child with Fanconi Anemia: A Case Report and Review of the Literature Pediatric Pathology & Laboratory Medicine. ,vol. 15, pp. 597- 607 ,(1995) , 10.3109/15513819509026995
Hessam Nowzari, Michael G. Jorgensen, Thai T. Ta, Adolfo Contreras, Jørgen Slots, Aggressive periodontitis associated with Fanconi's anemia. A case report. Journal of Periodontology. ,vol. 72, pp. 1601- 1606 ,(2001) , 10.1902/JOP.2001.72.11.1601
Stephen Levinson, Kent A. Vincent, Multifocal osteosarcoma in a patient with Fanconi anemia. Journal of Pediatric Hematology Oncology. ,vol. 19, pp. 251- 253 ,(1997) , 10.1097/00043426-199705000-00014