Polyunsaturated Fatty Acid (PUFA) Status in Pregnant Women: Associations with Sleep Quality, Inflammation, and Length of Gestation

摘要: Mechanistic pathways linking maternal polyunsaturated fatty acid (PUFA) status with gestational length are poorly delineated. This study examined whether inflammation and sleep quality serve as mediators, focusing on the antiinflammatory ω-3 docosahexaenoic (DHA; 22:6n3) proinflammatory ω-6 arachidonic (AA; 20:4n6). Pregnant women (n = 135) provided a blood sample completed Pittsburgh Sleep Quality Index (PSQI) at 20-27 weeks gestation. Red cell (RBC) levels were determined by gas chromatography serum inflammatory markers [interleukin (IL)-6, IL-8, tumor necrosis factor-α, IL-1β, C-reactive protein] electrochemiluminescence using high sensitivity kits. Both higher IL-8 (95% CI 0.10,3.84) poor 0.03,0.28) served significant mediators lower DHA:AA ratios shorter Further, serial mediation model moving from ratio → of gestation was statistically 0.02, 0.79). These relationships remained after adjusting for depressive symptoms, age, BMI, income, race, smoking. No interactions race observed in relation to continuous variable. However, interaction between predicting preterm birth (p 0.049); among African Americans only, odds decreased increased 0.048). data support role both less optimal RBC PUFA American European suggest that African-Americans have greater risk context low ratio.