Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy

作者: Pere Domingo , Maria del Carmen Cabeza , Ferran Torres , Juliana Salazar , Maria del Mar Gutierrez

DOI: 10.1371/JOURNAL.PONE.0057347

关键词: ImmunologyLipodystrophyPancreatitisStavudinePeripheral neuropathyHiv infected patientsAcute pancreatitisThymidylate synthasePancreatitis complicationsMedicineGeneral Biochemistry, Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesGeneral Medicine

摘要: Background Low expression thymidylate synthase (TS) polymorphism has been associated with increased stavudine triphosphate intracellular (d4T-TP) levels and the lipodystrophy syndrome. The use of d4T acute pancreatitis peripheral neuropathy. However, no relationship ever proved between TS polymorphisms and/or

参考文章(37)
Pedro Cano-Soldado, Jordi P. Guallar, Pere Domingo, Marta Giralt, Joan C. Domingo, Francesc Villarroya, F Javier Casado, Marcal Pastor-Anglada, Ivette Aymerich, Marta Alegre, Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antiviral Therapy. ,vol. 12, pp. 853- 863 ,(2007)
Villaroya F, Martínez E, López-Aldeguer J, Domingo P, Estrada, Fat Redistribution Syndromes Associated with HIV-1 Infection and Combination Antiretroviral Therapy Aids Reviews. ,vol. 14, pp. 112- 123 ,(2012)
Jennifer E Vela, Michael D Miller, Gerald R Rhodes, Adrian S Ray, None, Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools. Antiviral Therapy. ,vol. 13, pp. 789- 797 ,(2008)
Robert L. Murphy, Robert A. Parker, Robert R. Redfield, Ronald B. Reisler, Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 adult AIDS clinical trials group studies: lessons learned. Journal of Acquired Immune Deficiency Syndromes. ,vol. 39, pp. 159- 166 ,(2005)
Maria Gracia Mateo, Maria del Mar Gutierrez, Francesc Vidal, Pere Domingo, Drug safety evaluation profile of stavudine plus lamivudine for HIV-1/AIDS infection. Expert Opinion on Drug Safety. ,vol. 11, pp. 473- 485 ,(2012) , 10.1517/14740338.2012.676639
Colette J Smith, Christian H Olsen, Amanda Mocroft, Jean Paul Viard, Schlomo Staszewski, George Panos, Therese Staub, Anders Blaxhult, Norbert Vetter, Jens D Lundgren, The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study. AIDS. ,vol. 22, pp. 47- 56 ,(2008) , 10.1097/QAD.0B013E3282F03094
David J. Riedel, Kelly A. Gebo, Richard D. Moore, Gregory M. Lucas, A Ten-Year Analysis of the Incidence and Risk Factors for Acute Pancreatitis Requiring Hospitalization in an Urban HIV Clinical Cohort Aids Patient Care and Stds. ,vol. 22, pp. 113- 121 ,(2008) , 10.1089/APC.2007.0034
Todd Hulgan, David W Haas, Jonathan L Haines, Marylyn D Ritchie, Gregory K Robbins, Robert W Shafer, David B Clifford, Asha R Kallianpur, Marshall Summar, Jeffrey A Canter, Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS. ,vol. 19, pp. 1341- 1349 ,(2005) , 10.1097/01.AIDS.0000180786.02930.A1