Antitussive Effects of the Leukotriene Receptor Antagonist Montelukast in Patients with Cough Variant Asthma and Atopic Cough

摘要: ABSTRACT Background Chronic cough is the only symptom of variant asthma (CVA) and atopic (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness AC. To evaluate antitussive effect montelukast, a antagonist, CVA Methods Seventy-five patients with chronic received diagnostic bronchodilator therapy oral clenbuterol hydrochloride for 6 days. Of 75 patients, 48 27 met simplified criteria AC, respectively. Patients were randomly divided into 3 groups: clenbuterol, montelukast plus clenbuterol. AC 2 placebo. The efficacy treatment was assessed subjective scale (0 meant “no cough” 10 denoted “cough as bad at first visit”). scale, pulmonary function test, peak expiratory flow rate (PEF) evaluated before after weeks treatment. Results In 2-week all significantly decreased scores superior alone. group, PEF values morning evening increased compared did not differ between group placebo group. Conclusions Montelukast confirmed suppress non-productive whereas it