Synthesis, characterization and antitumor activity of benzalde- hyde nitrogen mustard picolinoyl hydrazone complexes
作者： Changzheng Li , Liufang Wang , Xiaogi Meng , Hong Zhao
关键词: Biological activity 、 Chemistry 、 Octahedron 、 Human liver cancer 、 Stereochemistry 、 Catalysis 、 Organometallic chemistry 、 Tetrahedral molecular geometry 、 Hydrazone 、 Antitumor activity
摘要: CuII, NiII, CoII, ZnII and CdII complexes of picolinamido-4-bis(2-chloroethyl)aminobenzaldimine (PBAB) have been synthesized characterized by elemental analysis, conductivity, i.r. u.v.-vis. e.p.r. spectra. The results suggest a square planar structure for the CuII complex, tetrahedral geometry an octahedral CoII NiII complexes. screened antitumor activity against SMMC-7721 human liver cancer cell line; all them exhibit biological at high concentrations line studied synergic effect between PBAB is evident.
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