Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives
作者： Hessa H. Al-Rasheed , Essam N. Sholkamy , Monirah Al Alshaikh , Mohammed R. H. Siddiqui , Ahmed S. Al-Obaidi
DOI: 10.1155/2018/8507567
关键词:
摘要: The present work represents the synthesis, characterization, and antimicrobial studies of novel series 2,4-bis(hydrazino)-6-substituted-1,3,5-triazine their Schiff base derivatives. IR, NMR ( ), elemental analysis, LC-MS characterized prepared compounds. biological activity target products was evaluated as well. Twenty-two compounds were selected according to solubility in aqueous DMSO. Only eight showed good against pathogenic bacteria did not show antagonistic effect fungus Candida albicans. Two 4k 5g have wide-range presently Gram-positive Gram-negative while other (4f, 4i, 4m, 5d, 6i, 6h) specific or bacteria. minimum inhibitory concentration (MIC, μg/mL) 4f, 4k, 6h Streptococcus mutans 62.5 μg/mL, 100 μg/mL, 31.25 μg/mL, respectively. MIC 5g, Staphylococcus aureus 6i Salmonella typhimurium compound Escherichia coli 62.5 μg/mL.
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