A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections

摘要: Severe dengue virus (DV) infections can cause the life-threatening condition hemorrhagic fever, which is characterized by a severe plasma leak, thrombocytopenia, hemorrhage, and, in cases, circulatory collapse and death. There now much evidence that pre-existing immunity to DV enhance disease when an individual becomes infected on second or sequential occasion. It has been shown contrast dendritic cells (DC), noninfected bystander DC underwent maturation infection. In this study, we show TNF-alpha type I IFN contribute of DC, whereas inhibition DV-infected be overcome activated T cells. Furthermore, IFN-gamma-inducible chemokines, CXCL9, 10, 11 produced are greatly amplified presence DV-specific The chemokine secretion also enhanced coculture HUVEC with either Finally, found close correlation between serum level these three chemokines severity.