Circadian variations in human resting submandibular saliva flow rate and composition

摘要: Abstract Circadian variations have been demonstrated in unstimulated submandibular saliva from 15 subjects for flow-rate, pH and concentrations of sodium, potassium, calcium, chloride, inorganic total phosphate, protein, nitrogen carbohydrate. Calcium protein rhythms were found only 12 calcium less reproducible day to than other rhythms. A combination a fundamental sine wave 24 hr period its first harmonic was fit the data 164 180 cycles studied. The salivary constituents did not appear be due rhythm shown by flow-rates. Rhythms similar phasing that oral temperature with exception those chloride carbohydrate concentrations. extent circadian variation maximum minimum approx 40–50 per cent mean value most constituents. Changes concentration components are likely least early afternoon. Considerable between timing found.